Sterilizing & Depyrogenation Tunnels
Sterilizing & Depyrogenation Tunnels
The Sterilisation & Depyrogenation Tunnels are engineered to provide reliable, efficient, and contamination-free processing of glass containers used in pharmaceutical manufacturing. Designed with high precision and built to meet international regulatory standards, these tunnels ensure consistent dehydrogenation performance, energy-efficient operation, and seamless integration with upstream washing systems and downstream filling machines.
Using a Continuous Hot-Air Laminar Flow process, the tunnels significantly reduce the risk of re-contamination compared to traditional batch depyrogenation ovens. Glass containers pass through carefully controlled heating, holding, and cooling zones, guaranteeing validated sterilisation while fully preserving container integrity.
Types of Series:
Why Choose URL 3S?
URL 3S stands as a trusted partner in advanced pharmaceutical sterilisation technology, backed by decades of engineering expertise. Venera depyrogenation tunnels are globally recognised for their reliability, precision, and adaptability across regulated markets. Each system is designed with a strong focus on:
- Sterility assurance through validated hot-air laminar flow
- Energy-efficient operation with optimised airflow and heat recovery
- Operator-friendly automation featuring PLC + HMI and advanced data recording
- Full regulatory compliance, including EU GMP, 21 CFR Part 11, WHO GMP, GAMP, and PIC/S
This combination of engineering quality and regulatory readiness makes Venera tunnels a preferred choice for sterile injectable manufacturing worldwide.
Common Advantages Across All Tunnels
Validated Sterility
Precise hot-air laminar flow technology ensures effective depyrogenation with minimal contamination risk.
Advanced Automation
PLC + HMI system provides user-friendly, menu-driven operation with recipe management and comprehensive process data recording.
Regulatory Compliance
Fully compliant with EU GMP standards and 21 CFR Part 11 requirements for electronic records, audit trails, and data integrity
HEPA / High-Temperature Filtration
High-efficiency filtration ensures a clean, sterile environment throughout all tunnel zones.
Seamless Integration
Compatible with industry-standard washing and filling equipment—suitable for both new lines and retrofit upgrades.
Energy Efficiency
Optimised airflow and heat recovery design help reduce overall energy consumption.
Customisation & Space Efficiency
Tailor-made configurations for specific throughput, layout, and minimal cleanroom footprint.
Robust Construction
Engineered with high-quality materials and durable fabrication for reliable, long-term, trouble-free operation
Depyrogenation Tunnel Series – Comparison Overview
| Feature / Specification | AX Series – Ampoule | CX Series – Cartridge | VX Series – Vial (SVP & LVP) |
|---|---|---|---|
| Container Type | Ampoules (various capacities) | Pharmaceutical cartridges | Vials – Small & Large Volume Parenterals |
| Lateral Support | Traveling fabricated support that moves with the conveyor for stable, breakage-free handling | Traveling fabricated support ensuring smooth transfer and negligible breakage | Fixed solid fabricated lateral support with robust mounting for enhanced vial stability |
| Breakage Prevention | Extremely low ampoule breakage due to traveling support | Extremely low cartridge breakage due to traveling support | Heavy-duty fixed support minimises vial breakage risk |
| Automation | PLC + HMI with recipe management, IPC, SCADA, and chartless recorder for secure data compliance | Same as AX Series | Same as AX & CX Series |
| Integration | Compatible with standard ampoule washing & filling machines | Seamless integration with cartridge washing & filling lines | Seamless integration with vial washers and filling machines |
| Filtration | HEPA / high-temperature filters | HEPA / high-temperature filters | HEPA / high-temperature filters |
| Compliance | EU GMP, US FDA (21 CFR), 21 CFR Part 11, WHO GMP, GAMP, PIC/S, and regional authorities (SFDA, ANVISA, HSA) | Same as AX Series | Same as AX & CX Series |
| Applications | Ampoule-based injectables | Cartridge-based drug delivery systems (e.g., prefilled systems) | Vial-based injectables, vaccines, biologics, SVP & LVP |